iSAVE

The iSAVE uses a series of valves and flow regulators in parallel limbs to effectively maintain the desired tidal volume and positive end-expiratory pressure for each patient, customizing therapy for each patient. This device aims to provide a personalized respiratory care, since it multiplexes a ventilator to two patients and customize treatment to each patient’s respiratory needs. The iSAVE enables patient-specific volume and pressure control, have valves to mitigate cross-contamination between patients and accommodates changing patient mechanics.

Additionally, it offer increased safety and reduced oversight burden by having a portable monitor, enabling monitoring outside of patient rooms in a centralized ICU space, reducing exposure risk to physicians and nurses, centralizing workflow and decreasing nursing burden.

iSAVE show ease of use and assembly, since its features, alarms and management is similar to the existing respiratory monitors, making it familiar to users. It can be assembled in less than 10 minutes, even by a non-medical technician.

Provided by the manufacturer (AIMED Solutions)

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iSAVE has been validated using benchtop models as well as in vivo studies on large mammals, demonstrating its potential to deliver multiplexed and personalized ventilation through a system of valves and sensors, with embedded safety measures.  The results show that the system enables patient-specific titration of V_T, inspiratory pressure, and PEEP, significantly amplifying the capacity of a single ventilator. In a set of scenarios mimicking the clinical evolution of patients with acute respiratory distress syndrome (ARDS) and sudden events that could jeopardize the ventilation of other patients, the system is able to handle circuit dependencies and deliver the desired therapeutic parameters to each channel. These results indicate the potential for rapid translation into clinical use to address the current ventilator shortage as a result of the COVID-19 pandemic.

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